Ask the Herbalist: All About Anticancer Herbs

Ask the Herbalist: All About Anticancer Herbs

December/January 2012
http://www.herbcompanion.com/health/ask-the-herbalist-anticancer-herbs-zm0z11djzdeb.aspx

By Linda B. White, M.D.


Q. Reading all of the reports on cancer prevention is really confusing me. Which anticancer herbs should I include in a daily regimen to stay healthy and reduce my risk of cancer?

A. First off, I’m glad to hear that you want to act now to reduce your cancer risk. Cancer takes years to develop. Prevention, if possible, is preferable to treatment. Avoid known carcinogens such as tobacco smoke, and have the routine screening tests that catch cancer in early, more-treatable stages.

As always, a healthy lifestyle is key. Eat a plant-based diet, exercise regularly and get enough sleep. Those strategies will also help keep your weight under control. Obesity raises the risk of diabetes, and both conditions are associated with an increased risk of cancer.

A plant-based diet can help shield you from cancer because plants are rich in anti-inflammatory and antioxidant substances that help them (and us) withstand exposure to ultraviolet radiation, air pollution and other noxious substances. (Oxidative damage and inflammation promote cancer as well as a number of other chronic diseases.) Furthermore, some plant chemicals enhance the body’s detoxification systems, stimulate the immune system and have direct anticancer effects.

Weeds are the true survivors. They burst through sidewalk cracks and weather pollution, drought, neglect and outright abuse. Researchers have only begun to investigate the anticancer effects of plants like dandelion (Taraxacum officinale) and stinging nettle (Urtica dioica). Nevertheless, I recommend including those two nutrition powerhouses in your diet. If you have access to fresh, pesticide-free leaves, you can steam or sauté them. (Use gloves when picking nettles, as they sting until cooked.) You can also drink infusions of the dried or fresh leaves.

Other foods to include are cruciferous vegetables, asparagus, and Alliums, such as garlic and onions, which all contain sulfurous anticancer compounds. Lycopene, a carotenoid chemical found in high concentrations in tomatoes, pink grapefruit, watermelon and guava, has anticancer action. Cooked tomato products are best, as the processing increases the body’s ability to absorb lycopene. The same is true of the isoflavone genistein, found in soybeans.

Another simple strategy is to increase your consumption of polyphenol-rich foods. Polyphenols, such as flavonoids, contribute to the plant’s color. For instance, fruits with deep red, purple and blue colors—red grapes, cranberries, blueberries, pomegranates—all have anticancer effects. But some powerful cancer-fighting, polyphenol-rich plants and anticancer herbs, such as green tea, turmeric and milk thistle, do fall outside the blue-purple color scheme.

Black, green and oolong tea all come from the same plant—Camellia sinensis. Population studies link higher tea consumption with a reduced risk of gastrointestinal, pancreatic, bladder, prostate, ovarian, uterine and breast cancer. Green tea is particularly rich in a polyphenol called epigallocatechin gallate. In lab research, it inhibits cancer cell formation, proliferation, invasiveness, and metastasis and provokes cancer cell death. Aim for three to five cups of green tea a day.

Turmeric (Curcuma longa) and its botanical cousin ginger (Zingiber officinale) are anticancer herbs that contain the potent anti-inflammatory, antioxidant, and anticancer polyphenols curcumin and gingerol, respectively. Most of the cancer research has focused on curcumin, which has multiple anticancer effects. It protects against DNA mutations; stimulates enzymes that repair damaged DNA and those that detoxify carcinogens; inhibits tumor formation, growth and migration; discourages angiogenesis (the creation of blood vessels that feed the cancer); and induces cancer cells to die.

However, curcumin is soluble in fat but not water, isn’t well-absorbed from the intestinal tract into the bloodstream, and breaks down quickly. Some supplement manufacturers improve bioavailability by combining it with bromelain (an enzyme in pineapple), piperine from pepper, or phosphatidylcholine. Cancer researchers have been working to create stable formulations that could be given intravenously to people undergoing cancer treatment.

The optimal dose for curcumin is not clear. In the meantime, eat curried vegetables. Turmeric is the main ingredient in curry spice. The pepper in the curry blend and the oil used in cooking will aid curcumin absorption.

While better known as an herb that protects the liver, milk thistle (Silybum marianum) also has cancer-protective effects. It contains an antioxidant, anti-inflammatory flavonoid complex called silymarin. Research shows that it promotes repair of DNA, blocks angiogenesis, and suppresses proliferation and metastasis of a variety of cancers.

You can take milk thistle as a tincture or standardized extract. You can also make the ground seeds into tea or sprinkle them atop foods. Milk thistle’s delicious relative, the artichoke (Cynara scolymus), also contains polyphenols.

Consumption of garlic (Allium sativum) and onion (Allium cepa) is associated with a reduced risk of some cancers. Lab studies further support this anticancer action of these anticancer herbs. Garlic increases enzymes that detoxify carcinogens, inhibits proliferation of cancer cells, induces cancer cell death and boosts immunity. Crush the bulb and allow it to sit for 10 minutes before consuming, which will increase an active ingredient called allicin. Because heat deactivates allicin, use raw, minced garlic in dressings, dips, soups and sauces, or add it to hot food just before serving.

Edible mushrooms contain highly branched polysaccharides called beta-glucans and other ingredients that both enhance immunity and have anticancer properties. Eating mushrooms correlates with a lower risk of breast cancer. Even the pedestrian button mushroom available at most supermarkets can enhance immune cell functions involved with cancer containment. Three of the better-researched medicinal mushrooms are shiitake, maitake and reishi.

Shiitake (Lentinula edodes) has immune-enhancing and anticancer effects. Asian research shows that an extract called lentinan enhances survival time in people with cancer. Due to poor oral absorption, lentinan is given by intravenous or intramuscular injections. Other components of shiitake, such as LEM (Lentinula edodes mycelia) extract, are active when taken by mouth. The fresh mushroom is delicious sautéed (with or without garlic). The dried mushroom can be taken in tea or soup. Concentrated extracts are also available.

Research on purified maitake (Grifola frondosa) extracts called “D-fraction” and “MD-fraction” demonstrate several anticancer actions: protection of healthy cells from becoming cancerous; inhibition of the growth and spread of tumors; induction of cancer cell death; enhancement of the effectiveness of anticancer drugs; and mitigation of some of their side effects. Maitake also increases natural killer cells, immune cells that attack tumor cells.

Maitake extracts produce benefits when taken by mouth. However, research in humans is scant and exact dosages aren’t yet defined. You can also consume this anticancer herb in tea or as a food (in soups, stir-fry, etc.). Higher-end grocery stores carry fresh maitake, also called “hen of the woods.”

In Traditional Chinese Medicine, reishi (Ganoderma lucidum) has the reputation of promoting health and longevity in people with and without cancer. Lab research shows that reishi extracts inhibit the proliferation and spread of breast, prostate, lung and liver cancer cells; stimulate cancer cells to die; and block the formation of new blood vessels to tumors. Reishi and green tea have a synergistic effect in thwarting the ability of breast cancer cells to invade and migrate.

Human trials have recently begun. Two studies showed that reishi enhances immune function in some people with advanced cancer. You can take reishi in teas, tinctures, syrups, tablets or standardized extracts.

Linda B. White, M.D., is a visiting assistant professor in the Integrative Therapies Program at Metropolitan State College of Denver.

It is all about your perspective...

One day, the father of a very wealthy family took his son on a trip to the country with the express purpose of showing him how poorer people live. They spent a couple of days and nights on a farm of what would be considered a very poor family. On their return from their trip, the father asked his son, “How was the trip?” “It was great, Dad.” “Did you see how poor people live?” the father asked. “Oh yeah,” said the son. “So, tell me, What did you learn from the trip?” asked the father. The son answered: “I saw that we have one dog and they had four. We have a pool that reaches to the middle of our garden and they have a creek that has no end. We have imported lanterns in our garden and they have the stars at night. Our patio reaches to the front yard and they have the whole horizon. We have a small piece of land to live on and they have fields that go beyond our sight. We have servants who serve us, they have friends to protect them.” The boy’s father was speechless. Then his son added, “Thanks Dad for showing me how poor we are.” Isn’t perspective a wonderful thing? Makes you wonder what would happen if we all gave thanks for everything we have, instead of worrying about what we don’t have.

Live well!

Terms of the Trade: Analgesics

They relieve pain without causing loss of consciousness. They also relieve pain by reducing cramping in muscles, also called antispasmodics.

Example herbal analgesics include willow bark, meadowsweet herb, hops flower, dogwood root bark, yellow jessamine root, black cohost root, and lavender essential oil.

Here is an article I posted earlier in my blog about the best herb for pain relief:
http://www.herbcompanion.com/health/the-best-herbs-for-pain-relief.aspx

The question to ask when deciding which remedy to use is What type of pain will be remedy relieve?

Ever Wonder if Emotions Cause Cancer...?

The following list shows some of the relationships between conflict emotions and target organs for cancer.

Adrenal Cortex: Wrong Direction. Gone Astray
Bladder: Ugly Conflict. Dirty Tricks
Bone: Lack of Self-Worth. Inferiority Feeling
Brain: Tumor Stubborness. Refusing to Change Old Patterns. Mental Frustration
Breast (Milk Gland): Involving Care or Disharmony
Breast (Milk Duct): Separation Conflict
Breast (Left): Conflict Concerning Child, Home, or Mother
Breast (Right): Conflict with Partner or Others
Bronchioles: Territorial Conflict
Cervix: Severe Frustration
Colon: Ugly Indigestible Conflict
Esophagus: Cannot Have it or Swallow it
Gall Bladder: Rivalry Conflict
Heart: Perpetual Conflict
Intestines: Indigestible Chunk of Anger
Kidneys: Not Wanting to Live. Water or Fluid Conflict
Larynx: Conflict of Fear and Fright
Liver: Fear of Starvation
Lungs: Fear of Dying or Suffocation, including Fear for Someone Else
Lymph Glands: Loss of Self-Worth associated with the Location
Melanoma: Feeling Dirty, Soiled, Defiled
Middle Ear: Not being able to get some Vital Information
Mouth: Cannot Chew It or Hold It
Pancreas: Anxiety-Anger Conflict with Family Members. Inheritence
Prostate: Ugly Conflict with Sexual Connections or Connotations
Rectum: Fear of Being Useless
Skin: Loss of Integrity
Spleen: Shock of Being Physically or Emotionally Wounded
Stomach: Indigestible Anger. Swallowed Too Much
Testes and Ovaries: Loss Conflict
Thyroid: Feeling Powerless
Tumor (in location): Nursing old Hurts and Shocks. Building Remorse
Uterus: Sexual Conflict

Cancer occurs at the cellular level. And there are a number of factors that create stress on the body's cells, causing them to become (1) depleted of adrenaline, (2) high in sugar and (3) low in oxygen, where they are more prone to mutate and become cancerous. The higher the sugar content of the cell caused by a depletion of adrenaline, and the lower the oxygen content, the greater the likelihood of normal cells mutating and becoming cancerous.

Read more: http://www.articlesbase.com/cancer-articles/emotional-causes-of-cancer-negative-emotions-in-the-body-can-cause-cancer-very-interesting-article-906066.html#ixzz10TJw4Ot1
Under Creative Commons License: Attribution

Terms of the trade - Alternatives

ALTERNATIVES

They are also known as blood purifiers and they are used in treating toxicity of the blood, infections, arthritis, cancer and skin eruptions.

They do not possess a single drug-like action that works only in specific areas, such as the lymphatic circulation or the skin, but their actions are general, systemic and broad-spectrum.

These are herbs that gradually restore proper function to the body; increasing health and vitality. Some support waste elimination processes via the kidneys, liver, lungs, or skin. Others stimulate digestive function or provide antimicrobial actions, while others simply work!

Examples of alternatives:
Red Clover is used to treat cancer because of its effects on protein assimilation.
Echinacea is used to neutralize acid conditions in the blood associated with a stagnation of lymphatic fluids.
Sarsaparilla may be used when diuretic properties are needed, as with infections.
Dandelion root combines hepatic tonic properties and diuretic properties and is particularly useful for treating chronic problems of blood toxicity.
Elder flowers have diaphoretic properties and are used to purify the blood during treatment of colds and flus.

Herbal healing works!

If you are interested in herbal healing, The B.O.S.S. Group can help. Call us at 303.886.0673 to schedule an appointment.

Natural Ways to Treat Diabetes

Natural Ways To Treat Diabetes

By Michael Castleman

Nearly 18 million Americans are now diabetic—triple the 1983 rate. If current trends continue, 37 million American adults will be living with diabetes by the end of 2015. The good news is that type 2 diabetes—the type 95 percent of American diabetics have—can be completely eliminated. In most cases, all it takes is lifestyle adjustments complemented by herbal medicine.

(Eat To Beat Diabetes.)

Diabetes is two different diseases, both involving the hormone insulin. In type 1, which typically strikes before age 25 and only accounts for about 5 percent of the disease, the pancreas stops producing insulin, which is required to usher blood sugar (glucose) into the body’s cells. Type 1 diabetics must inject insulin. Type 2 diabetes typically develops after age 40, either because the pancreas does not produce enough insulin, or because the cells become “resistant” and can’t use it.

(Controlling Diabetes with Exercise.)

In both types of diabetes, sugar builds up in the blood and causes the blood to become sticky. Eventually, this sticky blood gums up the blood vessels and causes the condition’s complications: cardiovascular disease (heart disease and stroke); poor wound healing; and problems with the eyes, kidneys, legs, nervous system and sexual organs.

Type 1 diabetes is caused by bad luck. Type 2 is strongly associated with obesity and the lifestyle that causes it: lack of exercise and a diet low in fruits and vegetables, and high in sugar, fat and animal products. As weight increases, the body’s cells become insulin-resistant.

Unlike type 1 diabetes, which has a fairly sudden onset, type 2 develops slowly, over years, as weight rises. Because of its slow development, type 2 diabetes rarely produces dramatic symptoms, and many people with the disease have no idea they have it.

There are other risk factors for type 2 diabetes beyond obesity, but these risk factors are by no means destiny. Even in people with a family history, lifestyle adjustments can prevent the disease or eliminate it. Researchers at the University of Texas Health Sciences Center in San Antonio followed 3,682 people with type 2 diabetes for seven years. During that time, diet modifications, weight loss and exercise allowed 12 percent of them to become nondiabetic, according to a 1998 article in Diabetes Care.
Lifestyle Modifications

Regular exercise and weight loss can prevent and treat type 2 diabetes:

• UCLA researchers persuaded 652 type 2 diabetics to enroll in a medically supervised diet and exercise program. The participants took daily walks and ate a diet very low in fat and cholesterol and high in fruits, vegetables and beans. After just 26 days, their average blood sugar levels dropped 15 percent. Of those taking diabetes medications, 71 percent were able to discontinue them. Of those injecting insulin, 39 percent were able to stop.

• Finnish researchers recruited 522 middle-aged overweight adults who were not diabetic but showed signs of insulin resistance. Half of the participants, the controls, received general health advice. The other half exercised for 30 minutes a day and ate a lowfat diet with lots of fruits and vegetables. Four years later, the diet-exercise group had lost an average of nine pounds versus two pounds in the control group. Diabetes developed in 23 percent of the controls but in just 11 percent of the diet-exercise group.

“The evidence is overwhelming,” says Joe Pizzorno, former president of Bastyr University near Seattle, a leading naturopathic medical school. “Our Western diet and lifestyle cause type 2 diabetes. To prevent it, get regular exercise. Eat less saturated fat and cholesterol by reducing or eliminating animal products. And eat more fruits, vegetables, beans and whole grains.”

A plant-based diet helps prevent diabetes in three ways: First, compared with the typical American diet, it’s much lower in fat, so it helps control weight. Second, it’s high in fiber, which helps control blood sugar. And third, plant foods are rich in antioxidant nutrients, which improve the body’s ability to use insulin. As blood levels of antioxidants rise, diabetes risk drops. According to a new study, herbs and spices are among the top 50 dietary sources of antioxidants. For more about the study and the benefits of herbs and spices, see “Eat to Beat Diabetes."

San Francisco-based writer Michael Castleman is the author of 12 consumer health books, including The New Healing Herbs (Rodale, 2001).

9 Tips for the Safe Use of Herbs

9 Tips for the Safe Use of Herbs

By Linda B. White, M.D.

Humans, like most mammals, have turned to plants for food and medicine since our earliest times. No doubt some of our ancestors suffered the consequences of unfortunate choices along the way. If you read the book or watched the movie Into the Wild, you realize we sometimes still err, confusing a poisonous plant for edible greenery. People still mistake the death cap mushroom for something more savory. And a couple of years ago, I even found some teenage boys sitting along an irrigation ditch, fashioning poison hemlock stems into cigarette holders.

Nevertheless, most of the medicinal herbs sold in the United States are safe when taken in recommended dosages. More than 38 million Americans use herbs each year, yet the majority of calls to Poison Control Centers about plant ingestions have to do with people (usually children) and pets eating potentially poisonous house and garden plants—not medicinal herbs.

To ensure your experiences with medicinal herbs remain positive—without inadvertent mishaps—follow these nine basic guidelines.

1. Start with Food Herbs

You can bet on safety when you use herbs as foods—think garlic, ginger, nettles, dandelion greens, shiitake mushrooms, nettles, burdock root (also called gobo) and rosehips. Culinary herbs—thyme, oregano, turmeric, cayenne—are also low-risk. Externally applied herbs (compresses, poultices, salves) provide another good testing ground.

The next step is to begin experimenting with infusions (commonly known as “teas”). Many of the food herbs mentioned above can be dried, chopped, and steeped as tea. Extracts of herbs in alcohol (tinctures) or glycerin (glycerites) generally are more potent. Solid extracts, in which all the solvent has been removed, and carbon dioxide-extract herbs are stronger still. Standardized extracts are designed to have a consistent level of suspected active ingredients from batch to batch. This process allows for more precise dosing and easier use in research, but also makes the product closer to a drug.

2. Allergy-Prone? Proceed with Caution

Simon Mills, an internationally known herbal authority and coauthor of The Essential Guide to Herbal Safety (Elsevier, 2005), says, “Allergic reactions are the most common type of herbal side effect although still infrequent.” Sensitive people who handle plants or apply them to their skin could develop contact dermatitis (an itchy skin rash), and inhaling the herbs could aggravate hay fever or asthma. Allergic responses to ingested herbs include skin rash, stomach upset and, at the extreme, life-threatening anaphylaxis.

If you’re allergic to ragweed, you might react to other members of the aster family, such as chamomile, echinacea and feverfew. More rarely, people can have allergic reactions to cayenne, kava (a member of the pepper family), garlic and mints.

“If you are prone to allergic reactions, be careful with your herbal attempts,” Mills says. Try one new herb at a time. Start with half the recommended dose, then gradually increase to the full recommended amount. If you develop a rash, upset stomach, itchy eyes or sneezing, stop taking the herb. If your lips or throat begin to swell, seek emergency care.

3. Investigate Herb-Drug Interactions

If you are taking both herbs and pharmaceutical drugs, you’ll want to avoid two possible scenarios: 1) interfering with the drug’s effects, and 2) amplifying the drug’s effects.

An herb could interfere with a drug’s effects if it acts in the opposite way—for instance, drinking three cups of stimulating black tea or coffee after taking a sedative Valium. An herb also might lower blood levels of a medication, thus thwarting its intended action. St. John’s wort is famous for doing just that. By speeding liver enzyme systems that break down drugs, it reduces blood levels of a long list of medications, including some antihistamines, chemotherapeutic and anti-HIV drugs, warfarin and oral contraceptives.

Furthermore, St. John’s wort, which has a good track record as an antidepressant, shouldn’t be combined with pharmaceutical antidepressants because it can raise blood levels of the chemical serotonin to dangerously high levels.

Combining herbs with drugs that have similar actions can increase the drug’s desired effects or its unpleasant side effects, and the net effect could be good or bad. For instance, some Chinese studies have found astragalus (Astragalus membranaceus) augments some anti-cancer drugs and decreases the drugs’ side effects. (Note: Researchers used injectable forms of the herb.)

In other cases, too much of a good thing can be bad. Taking anticoagulant (“blood-thinner”) drugs (aspirin, warfarin, heparin) with therapeutic doses of anticoagulant herbs (garlic, ginkgo, ginseng and others), for example, can result in bleeding. It’s also wise to discontinue the use of such herbs seven to 10 days before surgery.

As a general rule, avoid mixing herbs and drugs with the same actions so you do not become overly stimulated, sedated, anticoagulated, etc. (For specific combinations to avoid, see Page 55.)

4. Know When to See Your Health-Care Provider

Sick infants should be seen immediately by a practitioner with pediatric training. Also seek the help of your health-care provider if you know, or suspect, you or another adult has a serious condition. Self-medication with herbs runs the risk of delaying or interfering with medical treatment, potentially with disastrous consequences. Even if you have a mundane illness, make a doctor’s appointment if three days of home care haven’t alleviated your symptoms. Please work in partnership with your physician.

Also, be sure to tell your physician about any herbs you are taking prior to scheduling surgery. Some herbs, especially those with anticoagulant action, should be discontinued seven to 10 days before surgery, or as your doctor advises.

5. Use Extra Caution When Giving Herbs to Children

Babies younger than 6 months (or around the time a child begins eating solid food) should not take herbs internally. Small amounts of gentle herbs can be applied to an infant’s skin via salves, oils, baths and compresses (a cloth dipped in herb tea).

For older children, dosages usually are calculated by weight. Take the child’s weight in pounds, divide it by 150 (an average adult weight) and multiply that number by the adult dose. For instance, if an adult dose is 100 mg and the child weighs 50 pounds, the child’s dose would be 30 mg (50/150 x 100 = 0.3 x 100 = 30 mg).

Children aren’t simply small adults, however. Some herbs generally regarded as safe for adults should not be given to kids. To find out more, ask an herbal expert or get a good book, such as Naturally Healthy Babies & Children by Aviva Romm (Storey Publishing, 2000).

6. Use Gentle Herbs when Pregnant or Nursing

Many plant constituents pass from the intestinal tract into the blood, across the placenta to the fetus’ blood and, later, into breast milk.

If you’re pregnant, you generally should avoid putting anything medicinal into your body. Avoid consuming herbs with laxative effects (senna, cascara sagrada, aloe); hormonal properties (licorice, black cohosh, dong quai, chaste tree, sage, red clover); or stimulant effects (guarana, kola, yerba mate, tea, coffee).

Food herbs usually are safe bets, particularly when used in quantities suitable for flavoring. While no obstetrician will tell you to cease cooking with garlic and oregano, some culinary herbs, such as sage and parsley, might not be recommended in higher therapeutic doses, notes Mills. Most experts agree pregnant women can take these herbs safely: ginger (no more than 1 gram a day to reduce nausea), raspberry leaf, echinacea, chamomile, bilberry (fruit, not leaf), cranberry, hawthorn, hibiscus flowers, rose hips, mullein, spearmint and nettles.

7. Be Wary of Imported Herbs

Some herbal products from Asia, India and the Middle East reportedly have been adulterated with undesirable plants and/or contaminated with heavy metals, sulfites, pesticides and other toxins. In Chinese herbal formulas, herbs can be blended with pharmaceutical drugs not mentioned on the label. Also, Aristolochia fangchi, which has been substituted for other herbs, has been linked to severe kidney damage. Rather than give up on Asian herbs, “I personally would stick to whole herbs I can see, then make my own formulations,” says Mills.

8. Use Essential Oils Wisely

Essential oils are extremely concentrated. Herbalist and aromatherapist Mindy Green gives the following rules for using them safely:

1) Don’t apply essential oils to any mucous membrane: mouth, ears, nose, eyes, vagina or rectum.

2) Don’t take essential oils by mouth, and keep the bottles out of the reach of small children.

3) Don’t apply undiluted essential oils to skin. The standard dilution is 10 to 12 drops of essential oil per one ounce of carrier oil (such as almond or jojoba). Use half that amount or less for people who are debilitated; those with sensitive skin; and for children 5 to 12 years old. Don’t use essential oils for children younger than 5.

4) Be cautious when inhaling or applying essential oils to the chest if you are prone to asthma.

9. Educate Yourself.

Anyone interested in herbal medicine should have a good reference book on herb safety.

Try: The Essential Guide to Herb Safety by Simon Mills and Kerry Bone (Elsevier, 2005); Herb Contraindications and Drug Interactions by Francis Brinker, N.D. (Eclectic, 2001); Botanical Safety Handbook by Michael McGuffin, et al (CRC, 1997); and The ABC Clinical Guide to Herbs by Mark Blumenthal, et al (Thieme, 2003).

Avoid these Herb-Drug Combos

As a precaution avoid combining the following herbs and drugs:

Herbs: Kava, California poppy, valerian, skullcap
Drugs: Tranquilizing drugs or alcohol

Herbs: Guarana, yerba mate, coffee, green or black tea
Drugs: Stimulating drugs, such as oral decongestants; asthma drugs, such as albuterol; or pure caffeine

Herbs: Therapeutic doses of American ginseng, Asian ginseng, bitter melon, cinnamon, prickly pear cactus or nopal, ivy gourd and gymnema
Drugs: Drugs that lower blood sugar

Herbs: Ginger, ginseng, garlic and ginkgo
Drugs: Anti-coagulant (blood-thinning) drugs, such as Warfarin

Herbs: St. John’s wort
Drugs: Antidepressants; amitriptyline, cyclosporine, digoxin, fexofenadine, indinavir, methadone, midazolam, nevirapine, phenprocoumon, simvastatin, tacrolimus, theophylline, warfarin, irinotecan; birth control pills

Know these Poisonous Plant Look-Alikes

If you plan to make your own herbal preparations from plants you’ve grown or gathered, be sure the plant is what you think it is. Consult a good basic book on plant identification, such as Peterson Field Guides: Eastern/Central Medicinal Plants and Herbs by Steven Foster and James A. Duke (Houghton Mifflin, 2000) and Western Medicinal Plants and Herbs by Steven Foster and Christopher Hobbs (Houghton Mifflin, 2002).

If you still aren’t sure of the plant’s identity, consult a local botanic garden, horticulture club or university extension program.

Wild Garlic/Onion (Allium canadense): Edible bulbs and leaves have characteristic onion odor. Used medicinally.
Death Camas (Zigadenus spp.): Bulb and leaves resemble wild onion; all parts are highly poisonous

Wild Carrot (Daucus carota): Young root is edible; older roots become woody and tough. Used medicinally.
Poison Hemlock (Conium maculatum): Leaves resemble wild carrot, but root is highly toxic. Stems have purple markings.

Comfrey (Symphytum officinale): Leaves sometimes used topically; do not take internally—can cause liver damage.
Foxglove (Digitalis purpurea): Leaf rosettes that emerge in spring often confused for comfrey with fatal results.

Herbs and Liver Damage

Herb expert James Duke, Ph.D., points out that many more herbs protect the liver than harm it. In fact, one of America’s favorite over-the-counter drugs, acetaminophen (Tylenol and other brands), is riskier than most herbs. Although safe within recommended dosages, acetaminophen overdoses (some of which occur among people simply trying to relieve their pain) are the main cause of acute liver failure, and contribute to 500 American deaths a year.

That said, the following herbs should be avoided, particularly in people with known liver disease, heavy drinkers (or users of recreational drugs), and those taking liver-taxing drugs, such as acetaminophen (Tylenol), aspirin, nonsteroidal anti-inflammatories (such as ibuprofen), corticosteroids, statins, tetracyclines and others).

Herbs that contain pyrrolizidine alkaloids: comfrey, coltsfoot, senecio, borage leaf and germander. Comfrey has gotten the most media attention for its connection to liver injury. In 2001, the Food and Drug Administration advised manufacturers to remove from the market comfrey products intended for internal use. Because this herb is a good wound healer, it’s often an ingredient in first-aid salves. Another PA-containing herb, butterbur, is available as a PA-free extract (Petadolex) for the prevention of migraine headaches and hay fever.

Kava (Piper methysticum). For many years, people of the South Pacific have consumed kava beverages with the single side effect of a scaly, yellowish skin condition with excessive use. Research showing concentrated kava extracts reduced anxiety spurred its widespread popularity. Although human studies didn’t register liver toxicity, cases of liver injury (some severe) cropped up several years ago. Most involved ingestion of kava extracts made with acetone or alcohol, and often along with alcohol or drugs that can be hard on the liver.

Mark Blumenthal, founder and executive director of the American Botanical Council, says, “no convincing proof of an inherent toxicity of kava exists,” despite ongoing research. And, while he believes kava to be relatively safe, “the jury is still out as to whether kava might cause liver injury, particularly in susceptible individuals.”

Steven Dentali, Ph.D., Chief Science Officer for the American Herbal Products Association, adds, “Considering the widespread consumption of kava beverage and the long history of apparent safe use, any toxic liver reactions are of course serious, but extremely rare.”

A general guideline: Don’t take herbs that have even a suspicion of harming the liver if you already have liver disease or regularly drink alcohol or use recreational drugs. Also avoid these herbs if you take a medication that can be toxic to the liver. Consult your health-care provider if you are unsure.

Linda B. White, M.D. is the coauthor of The Herbal Drugstore. An assistant professor, White teaches classes in herbal medicine in the Program in Integrative Therapeutic Practices at Metropolitan State College of Denver.